Pleuropulmonary Blastoma in Pediatric Lung Lesions

BACKGROUND: Pediatric lung lesions are a group of mostly benign pulmonary anomalies with broad spectrum clinical disease and histopathology. Our objective was to evaluate the characteristics children undergoing resection primary lesion identify preoperative risk factors for malignancy. METHODS: A retrospective cohort study conducted by using an operative database 521 managed at 11 children’s hospitals in United States. Multivariable logistic regression used examine relationship between malignancy, including pleuropulmonary blastoma (PPB). RESULTS: None 344 prenatally diagnosed had malignant pathology (P < .0001). Among 177 without history prenatal detection, 15 (8.7%) were classified as having tumor (type 1 PPB, n = 11; other 3; adenocarcinoma, 1) median age 20.7 months (interquartile range, 7.9–58.1). Malignancy associated DICER1 mutation 8 (57%) PPB cases. No systemic feeding vessel .0427). The sensitivity chest computed tomography (CT) detecting 33.3% (95% confidence interval [CI]: 15.2–58.3). revealed that increased suspicion malignancy CT bilateral significant predictors (odds ratios 42.15 [95% CI, 7.43–340.3; P .0001] 42.03 3.51–995.6; .0041], respectively). CONCLUSIONS: In pediatric masses initially after birth, approached 10%. These results strongly caution against routine nonoperative management this patient population. testing may be helpful given poor identifying pathology.